Postdoctoral researcher - Sequence-based protein coevolution (R2)

Application deadline:

The Computational Biology group, led by ICREA professor Alfonso Valencia, is looking for a postdoctoral researcher to work in the context of structural bioinformatics. The Life Sciences Department at the BSC integrates the independent research of senior scientists that work on various aspects of computational biology, ranging from bioinformatics for genomics to computational biochemistry and text mining. The Computational Biology group (http://life.bsc.es/compbio) is involved in multiple projects covering a wide range of topics including multilayer network modeling, epigenomics and computations systems biology. Recently the Computational Biology group has joined a consortium along with the Animal Health Research Center (CReSA) of the Institute of Agrifood Research and Technology (IRTA) and the IrsiCaixa AIDS Research Institute, funded with the support of Grifols. The consortium's strategy is to generate vaccines using variants SARS-CoV-2 proteins. The group has also participated as assessors in the recent CASP14 challenge. The candidate will work in collaboration with senior researchers in the Computational Biology Group of the Life Sciences Department as well as other research groups at the BSC. The work is in the framework of the research lines of the group, involving in personalized medicine and protein structure/function analysis, including the development of (co)evolution based methods. The Researcher will work in a highly sophisticated HPC environment, will have access to state-of-the-art systems and computational infrastructures, and will establish collaborations with experts in different areas both at international and local levels, in particular. The Researcher’s tasks will involve applying protein sequence and structure based methods for the prediction of protein-protein interfaces and contacts, specific protein interaction partners and the effect of single or multiple amino acid mutations in the stability of protein structures.