Detection and characterization of nanoparticles in biological cells and tissue using advanced microscopy techniques
We are currently accepting applications for the above mentioned position. This is a unique opportunity for highly motivated students recently graduated from the University in Physics or related fields to gain research experience in one of DIPC’s high-profile research teams.
In neurobiological research, engineered nanoparticles are used as next-generation tools to precisely record, modulate, and image neural activity at the cellular level. We need to understand how these particles distribute and persist within complex tissue to ensure both their biological safety and their efficacy during optical stimulation and targeted therapeutics.
The goal of this PhD project is to develop and apply advanced microscopy methods that can detect and characterize nanoparticles in biological cells and tissue. Specifically, you will explore optical phase imaging and IR nanoimaging to locate nanoparticles inside the biological cells and tissue. A key focus will be the measurement of the local temperature increase as a result of optical stimulation of the nanoparticles.
We will approach this project from the physical perspective, applying an experimental approach by building and testing optical microscopy platforms. At the same time, there is opportunity for theoretical model using numerical solvers to simulate optical microscopy. This project will fully integrate into the nanoneuro project and the Basque nanoneuro Network (B3N). As a result, you will work closely with other local research groups working on the topics of nanotechnology and neurotechnologies, allowing you to both benefit from and contribute to their expertise.