REF: IP-JAE-05.23

IMPORTANT: The interested person must send the Curriculum Vitae, the degree and the work life report MANDATORY through the CNIC application web, which can be found at the following link:
https://www.cnic.es/es/convocatoria/postdoctoral-researcher-lab-functional-genetics-oxidative-phosphorylation-system

Requests that are not sent through the CNIC website cannot be accepted

The Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) CNIC has been conceived to develop research of excellence, competitive and of international relevance in relation to cardiovascular diseases. The CNIC has a research center of 24,000 m2, located in Madrid, with more than 6,000 m2 for laboratories equipped with a state-of-the-art infrastructure and equipment.
Functions:
Incorporate a postdoctoral researcher to Dr. Jose A. Enríquez’s lab to carry out the functions mentioned below in relation to the Leducq project "Redox Regulation of Cardiomyocyte renewal, Exp: 17CVD04", which funding supports this contract.
• Animal handling procedures with murine models (heart failure models, cardiac function assessment, inducible genetic models)
• Molecular biology techniques (qRT-PCR, Western Blot, CRISPR-Cas9)
• Mitochondrial biology analysis (mitochondria isolation, BNGE, respirometry (Seahorse and Oroboros), spectrophotometric analysis of respiratory complexes, mitochondrial dynamics imaging analysis…)
• Cell culture techniques.
Mandatory Requirements:
1. PhD in the field of biomedicine obtained after 2021
2. At least 2 publications as author (research articles and/or reviews).
3. Certificated authorizations to perform research with animals, Functions A, B, C and D (Orden ECC/566/2015)
4. Cardiology teaching proven experience.
5. English Certification: First Certificate in English FCE or B2 or TOEFL 171-220 or IELTS 5.0, 5.5, 6.0.
Valuable Requirements
• C1. Experience in cardiology (theoretical background, echocardiography analysis, electrocardiogram analysis, treadmill experiments). (It will be valued by years or fraction of experience).
• C2. Experience with heart failure murine models (transverse aortic constriction, doxorubicin-induced cardiotoxicity) (It will be valued by years or fraction of experience).
• C3. Experience with murine genetic inducible models (Cre-LoxP system) (It will be valued by years or fraction of experience) 10 %.
• C4. Experience with molecular biology techniques (qRT-PCR, Western Blot, CRISPR-Cas9) (It will be valued by years or fraction of experience).
• C5. Experience with mitochondrial biology analysis (mitochondria isolation, BNGE, respirometry (Seahorse and Oroboros), spectrophotometric analysis of respiratory complexes, mitochondrial dynamics imaging analysis…) (It will be valued by years or fraction of experience).
• C6. Experience with RNAseq and proteomics analysis (It will be valued by years or fraction of experience).
• C7. Personal Interview.
We offer:
• Opportunity to work in a leading cardiovascular research institution equipped with state-of-the-art resources and technology.
• Integration in a young translational research team, in a highly competitive environment
• Start date: Inmediate
• “Contrato de actividades científico-técnicas, de duración indefinida, according to the article Artículo 23-bis de la Ley de la Ciencia (texto refundido Ley 14/2011, de 1 de junio, de la Ciencia, la Tecnología y la Innovación), funded by the project "Redox Regulation of Cardiomyocyte renewal, Exp: 17CVD04", Coordinators: Miguel Torres and Hesham Sadek, PI: JA Enriquez, as long as the selected candidate complies with the legal requirements for the formalization of the contract in accordance with the Spanish labor law.
Selection Plan:
The RESOLUTION OF THE SECRETARIAT OF STATE FOR PUBLIC FUNCTION APPROVING THE COMMON ACTION CRITERIA FOR THE RECRUITMENT PROCESSES IN THE STATE PUBLIC SECTOR ENTITIES of April 11, 2022, set forth in point 6.1 that “Unless a specific regulation establishes a merit-bases recruitment system (concurso), the competition (concurso-oposición) must be the recruitment system”
In CNIC, the specific regulations approved by the Foundation's board of trustees establish a merit-base recruitment system (concurso) including a personal interview.
At least three candidates with the highest score (as long as they reach the minimum of 65 points as a sum of criteria (C1-C4) will be interviewed. The candidate with the highest score will be hired given the total score (C1-C5) reaches 90 points
Composition of the Selection Commission:
• Head of the “Functional Genetics of the Oxidative Phosphorylation System (GENOXPHOS)” group
• Senior Technician of the “Functional Genetics of the Oxidative Phosphorylation System (GENOXPHOS)” group
• Research Office Manager
• Research Office Manager
• HR member

The CNIC guarantees, within its field of action, the principle of equal access to employment, and may not establish any direct or indirect discrimination, based on grounds of origin, including racial or ethnic origin, sex, age, marital status, religion or beliefs, political opinion, sexual orientation and identity, gender expression, sexual characteristics, trade union membership, social status, language within the State and disability, provided that workers are fit to perform the work or job in question.
By participating in the selection process, the participant agrees that their data appear in the public resolutions of the selection process. Such resolutions (provisional list of admitted and excluded, definitive list of admitted and excluded and resolution of the process) are published on the CNIC website.

Assessable criteria:
• C1- Experience in cardiology (theoretical background, echocardiography analysis, electrocardiogram analysis, treadmill experiments). (It will be valued by years or fraction of experience) - 20%
• C2- Experience with heart failure murine models (transverse aortic constriction, doxorubicin-induced cardiotoxicity) (It will be valued by years or fraction of experience) - 20%
• C3- Experience with murine genetic inducible models (Cre-LoxP system) (It will be valued by years or fraction of experience) - 10%
• C4- Experience with molecular biology techniques (qRT-PCR, Western Blot, CRISPR-Cas9) (It will be valued by years or fraction of experience) - 10%
• C5-Experience with mitochondrial biology analysis (mitochondria isolation, BNGE, respirometry (Seahorse and Oroboros), spectrophotometric analysis of respiratory complexes, mitochondrial dynamics imaging analysis…) (It will be valued by years or fraction of experience) - 10%
• C6- Experience with RNAseq and proteomics analysis (It will be valued by years or fraction of experience) -10%
• C7 – Personal Interview - 20%

"En caso de ausencia de alguno de los evaluadores se nombrará un evaluador alternativo de la misma área"