Postdoctoral Researchers ‘Mechanobiology in development and multicellular self-organization’

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

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The role

The position is expected to be filled by PhD-level candidates with experience in cell and developmental biology, mechanobiology and advanced fluorescence microscopy. The candidates will work within an ERC funded project that investigates the role of geometry and mechanical forces in embryo development and multicellular self-organization. In vivo methods and synthetic biology approaches will be employed to study the role of shape, size, and mechanical forces in tissue patterning and robust morphogenesis during early embryo development.

We are seeking highly motivated candidates with an excellent track record who are enthusiastic to work in an interdisciplinary research team at the interface of physics and biology. The candidates will further engage in a collaborative ERC consortium (Verena Ruprecht-CRG Barcelona, Vikas Trivedi-EMBL Barcelona, Matthias Merkel- Aix-Marseille University and Pierre-François Lenne-Marseille Aix-Marseille University).

About the team

The Ruprecht lab studies fundamental mechanisms regulating cellular morphodynamics, tissue plasticity and multicellular self-organization. The team employs an interdisciplinary approach that combines quantitative fluorescence microscopy, biophysical methods, synthetic biology approaches and in vivo model systems. Our team has recently identified that nuclear mechanosensing controls cellular mechano-plasticity in development (Venturini et al. Science 2020) and has elucidated mechanisms of developmental robustness via cellular error correction in the early embryo (Hoijman et al. Nature 2020). Our ultimate goal is to develop a mechanistic understanding how tissue form and function is robustly built and maintained by dynamic processes at the single cell level, with a focus on cellular mechano-signalling and morphodynamic plasticity.
The research group is part of the Quantitative Cell Biology Program and Systems and Synthetic Biology program at the CRG.

Whom would we like to hire?

Professional experience

Must Have
• You bring experience in mechanobiology and cross-disciplinary research
• You have expertise in fluorescence microscopy methods and quantitative data analysis

Desirable but not required/ Nice to have
• You have worked with in vivo or synthetic embryo model systems
• You have experience in microfluidics or microfabrication methods
• You are knowledgeable in the development of image processing and analysis tools

Education and training
• You hold a PhD degree in biology, physics, engineering or a related field with relevant qualifications

• You are fluent in English and have excellent communication and writing skills

Technical skills
• You bring an excellent scientific track record with eligibility for competitive postdoctoral funding schemes

• Motivated person with analytical problem-solving skills
• Willing to work in an interdisciplinary and collaborative research team

The Offer – Working Conditions
• Contract duration: 3 years
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales
• Target start date: From September 2023

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure

All applications must include:
1. A motivation letter addressed to Dr. Verena Ruprecht.
2. A complete CV including contact details.
3. Contact details of two referees.

All applications must be addressed to Dr. Verena Ruprecht and be submitted online on the CRG Career site -

Selection Process

₋ Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.

₋ Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.

₋ Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by 30/09/2023

ERC Synergy Grant

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