Predoctoral researcher in Cellular and molecular mechanobiology. Proyecto de Generación de Conocimiento 2022 by the Spanish Ministry of Science and Innovation

The Cellular and Molecular Mechanobiology Group is looking for a Pre-doctoral Researcher to work on nuclear mechanobiology. The cell nucleus is a central decision hub in cells, receiving inputs from the cell environment and integrating them to control cell function. In recent years, it has become clear that the nucleus receives not only biochemical signals but also mechanical forces, and that these forces regulate nuclear function. This implies that there are likely multiple regulatory mechanisms deciding when and how forces reach the nucleus, with potential implications in diseases such as cancer or fibrosis, where there are major mechanical alterations to tissues.

The candidate will carry out a PhD focused on the process of mechanotransduction, which is the conversion of mechanical forces into downstream biochemical signals (such as for instance transcription). More specifically, the candidate will explore different mechanisms by which cells can regulate whether forces reach or not the nucleus, and for how long. This will be studied in the context of fibroblasts and mesenchymal cells in a pancreatic cancer setting, which is characterized by a dramatic alteration in tissue mechanical properties.

This fellowship is associated with the research project Generación de Conocimiento, funded by the Spanish Ministry of Science and Innovation.