Introduction to the vacant position:
Dementia, including Alzheimer's, Lewy body Parkinson's, and others, is a growing health concern worldwide. These conditions are often associated with the formation and aggregation of neurotoxic misfolded oligomers such as amyloid-β, tau proteins, and α-synucleins. Understanding these harmful oligomers is essential to uncovering the molecular basis of these diseases. To investigate the protein aggregation dynamics and liquid-liquid phase separations, this project will use advanced TEM imaging in Liquid Phase. The research focuses on proteins associated with Alzheimer's and Parkinson's diseases, using a combination of simulations and liquid TEM imaging. Additionally, the project explores the impact of drugs and aggregation inhibitors on protein structures in liquid environments.
This interdisciplinary approach combines imaging science, physics, molecular engineering, and computational science and holds great promise for helping to create innovative treatments for neurodegenerative diseases causing dementia.We welcome individuals willing to combine experimental imaging with computational efforts. This is an exciting opportunity to be part of the Molecular Bionics group, a dynamic multidisciplinary team comprising chemists, physicists, mathematicians, engineers, and biologists. To learn more about our work, please visit our external website at https://www.molecularbionics.org.
This fellowship is associated to the research project Generación de Conocimiento, funded by the Spanish Ministry of Science and Innovation.