Postdoctoral position at Centro Andaluz de Biología del Desarrollo (CABD), Seville

Application deadline:

Juan    R.    Martinez - Morales    Lab ( jrmarmor@upo.es ) is recruiting    competitive postdoctoral  researchers  to  participate  in  an  interdiscipli nary  project on  c omparative tissue morphogenesis.

 

Research project/ Research Group description:

The  main  focus  of  our  laboratory  is  to  study  cellular  and  molecular  mechanisms involved  in  the  morphogenesis  of  the  vertebrate  eye.  Using  the  teleost  models zebrafish  and  medaka,  we  investigate  the  machinery  driving  the  folding  of  the  retinal neuroepithelium..  Although  it  is  generally  accepted  that  optic  cup  formation  follows  a tissue - intrinsic  program  in  vertebrates,  several  mechanisms  have  been  postulated (bas al  constriction,  rim  involution)  and  some  important  differences  in  cell  behaviour have been reported among species.

Many important questions still remain open. Which is the relative contribution of each mechanism to the folding of the optic cup? Do they act  in  a  cooperative  manner?  Do  they  have  the  same  regulatory  weight  in  different species? To answer these questions, we aim to integrate genetic information, imaging analysis   of   cell   shape   changes,   and   tensional   forces   distribution   into   coherent computation al models able to predict the key morphogenetic rules that shape the entire organ.  We  plan  to  extend  our  observations  to  mammalian  tissue,  by  examining  cell shape changes and tensions in 3D retinal organoids developed in vitro.

A key aspect of the  project is  to  understand  how  classical  signalling  events,  which  have  proved  to  be essential  for  the  proper  patterning  of  the  organ,  act  in  coordination  with  tensional forces. This highly interdisciplinary approach, combining genetics, imaging, biophysics and  computational  modelling  should  yield  information  relevant  not  only  to  understand optic cup formation, but also to deduce general self - organization principles of the living matter.

 

Relevant Publications:

Letelier et al. (2018a) Nat Genetics , Letelier et al (2018b) PNAS , Nicolás - Pérez et al (2016). eLife ; Gago - Rodr igues et al (2015). Nat Comm ; Tena et al (2014) Genome Research. 24(7): ; Bogdanovic et al (2012). Developmental Cell. 23 (4).

For a full list: https://www.ncbi.nlm.nih.gov/pubmed/?term=Martinez-morales+JR

 

Job position description:

We offer a one - year renewable contract and full support to apply for external funding. Given  the  interdisciplinary  character  of  the  project  above  described,  we  are seeking talented  and  highly  motivated  postdoctoral  researchers  with  a  background  either  in Developmental  Biology  or  in  Biophysics. Previous  experience  with  teleost  models  will be  well  received.  The  candidates  should  have  good  communication  skills,  critical  for ensuring the success of the team effort.

 

Contact information:

Email: jrmarmor@upo.es

Phone: + 34 954977827