Avizorex Pharma Novel therapies for Dry Eye Syndrome (DES) acting on eye surface temperature-sensitive fibers 09.02.2018

Novel therapies for Dry Eye Syndrome (DES) have been developed based on the research on the role of eye surface temperature-sensitive nerve fibers in tear film regulation. Dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. TRPM8 (transient receptor potential cation channel, subfamily […]

Keratinocytes Treatment of metastatic breast cancer

A study published in the Lancet Oncology by an international team led by Prof Rob E. Coleman (University of Sheffield) and Prof Roger R. Gomis (IRB Barcelona) identifies the effect of MAF amplification on the outcome of treatment with adjuvant zoledronic acid in early breast cancer. This new knowledge may be key to the early […]

T-ALL mouse model with inactivated CIC/CAPICUA (staining with CD3 antibodies highlighting aberrant T cells)./ CNIO ‘Capicua’ gene plays a key role in one of the most common types of childhood tumours, T-cell acute lymphoblastic leukaemia 06.02.2018

Researchers at the Spanish National Cancer Research Centre (CNIO) have discovered a genetic alteration that is directly involved in at least 10% of cases of one of the most common cancers in children, T-cell acute lymphoblastic leukaemia. In a paper published in Genes and Development, the scientists explain how the mice in which a specific […]

Breakfast Skipping breakfast associated with hardening of the arteries

The PESA study shows that people who regularly eat a ‘low energy’ breakfast (supplying less than 5% of recommended daily calorie intake) double their risk of developing atherosclerosis independently of classical cardiovascular risk factors. Skipping breakfast or eating very little at the start of the day doubles the risk of atherosclerosis. This is the latest […]