Nature Cell Biology: A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges 02.01.2023

A study carried out at theCentro Nacional de Investigaciones Cardiovasculares (CNIC) heralds a paradigm change in the field of mechanobiology. The study reveals that cells respond to forces of differing strength using use two distinct mechanisms, one mediated by minute, cup-like invaginations on the cell surface called caveolae and the other by newly discovered large […]

The Francisco Cobos Foundation Grants the 16th scientific career award o José Antonio Enríquez 22.12.2022

The Francisco Cobos Foundation granted its 16th Scientific Career Award to the Centro Nacional de Investigaciones Cardiovasculares (CNIC) researcher Dr. José Antonio Enríquez. The prize, endowed with €50,000, has been awarded for his contributions to the study of mitochondrial biogenesis in the functioning of the Mitochondrial respiratory chain and understanding of  the mitochondrial pathophysiology and […]

eLife:CNIC scientists identify the essential role of cell-surface "nanofolds" and "glue" in the mechanical response of cells

A study at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has revealed that subcellular structures called caveolae play an essential role in cell mechanics. The results suggest that impaired caveolar function could be involved in a variety of processes, including platelet aggregation, cardiovascular disease, fibrosis, and tumor formation. The study is published in eLifeand was […]

Nature: Researchers characterize rare, damaged cells that block the functions of their neighbour healthy cells and identify ways to neutralize them and improve tissue regeneration 21.12.2022

Researchers at the Universitat Pompeu Fabra (UPF), ICREA, CIBERNED, CNIC and Altos Labs, among other national and international collaborators, have characterized how damaged cells (senescent cells) that inevitably arise after injury negatively impact tissue regeneration, and how this mechanism operates actively in old age, but surprisingly also in young age. This negative action can be […]

Nature Cardiovascular Research: CNIC scientists identify the cause of arrhythmias and sudden death in Andersen-Tawil syndrome type 1

Two research groups at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered the cause of arrhythmias and sudden death in the rare disease Andersen-Tawil syndrome type 1 (ATS1), which is caused by mutations affecting potassium channels that regulate electrical activity and the intracellular calcium cycle in cardiac and skeletal muscle. The teams led by Drs. José […]

Blood: RXR, the cell protein that keeps blood stem cells young and fit 15.12.2022

The cell protein retinoid X receptor (RXR) is a key factor in the maintenance of hematopoietic stem cells, the immature stem cells that give rise to all the blood cell lineages. RXR ensures that these cells remain youthful and fit, thereby reducing the risk of developing myeloproliferative syndromes as the body ages. The study was […]

European Journal of Heart Failure: A promising drug treatment for patients with pulmonary hypertension associated with heart disease 12.12.2022

There is currently no specific treatment for pulmonary hypertension associated with heart disease, a highly prevalent condition with a poor prognosis. Now, a study from the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Hospital Clínic de Barcelona/IDIBAPS has shown that mirabegron, a drug that acts on the beta-3 adrenergic receptor, may have a beneficial effect […]

Las soluciones basadas en la naturaleza pueden desempeñar un papel clave en la adaptación al cambio climático

La ciudad de Sharm-El-Sheij (Egipto) acogió durante el mes de noviembre la 27ª Cumbre de la Convención Marco de Naciones Unidas para el Cambio Climático que tenía como objetivo central avanzar en la implementación y la acción climática global, tanto en materia de adaptación a los efectos del cambio climático como de mitigación, así como […]

Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis 29.11.2022

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a new therapeutic target for the prevention of heart failure linked to aortic stenosis. The study was led by Dr. Borja Ibáñez, Clinical Research Director at the CNIC, cardiologist at Hospital Universitario Fundación Jiménez Díaz, and member of the Spanish cardiovascular research network (CiberCV). […]

200 representantes de la Alianza SOMMa se reúnen 100xCiencia.6 22.11.2022

El Palacio Real de Pedralbes en Barcelona fue el escenario para el encuentro 100xCiencia.6: “Ciencia para el futuro. Construyendo un horizonte más justo y sostenible”, coorganizado por la alianza SOMMa y el Barcelona Supercomputing Center – Centro Nacional de Supercomputación (BSC-CNS) celebrado el pasado 3 de noviembre, que ha reunido a más de 200 asistentes […]

Relevo en la presidencia de la alianza SOMMa: María José Sanz sustituye a María Blasco 10.11.2022

María José Sanz directora del Basque Centre for Climate Change (BC3) asume la presidencia de la Alianza de Centros Severo Ochoa y Unidades María de Maeztu (SOMMa) sustituyendo a María Blasco directora del Centro Nacional de Investigaciones Oncológicas (CNIO) que ha concluido su periodo elegible tras dos años de mandato, recordando que “SOMMa tiene el […]

Circulation: Specific modifier genes determine the effect of mutations that cause non-compaction cardiomyopathy 07.11.2022

Non-compaction cardiomyopathy is a heart condition caused by defects that arise during fetal development and can have diverse health impacts in affected individuals, including sudden cardiac death. The Intercellular Signaling in Cardiovascular Development and Disease group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) previously reported that this disease can be caused by two distinct […]